1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid

Base Information

Chemical Name:1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid
CAS No.:1428795-12-3
Molecular Formula:C₁₆H₁₄FNO₅
Molecular Weight:319.289
Hs Code.:

Synonyms:1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid

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Technology Process of 1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid

There total 3 articles about 1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1428795-10-1
dimethyl 1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylate

: 1428795-12-3
1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid

Guidance literature:: dimethyl 1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylate; With ethanol; potassium hydroxide; at 90 ℃; for 18h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 1428795-11-2
dimethyl 1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylate

: 1428795-12-3
1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h

2: potassium hydroxide; ethanol / 18 h / 90 °C

With ethanol; caesium carbonate; potassium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 61128-73-2
tetrahydropyran-4-one oxime

: 1428795-12-3
1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / toluene / 2 h / 165 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h

3: potassium hydroxide; ethanol / 18 h / 90 °C

With 1,4-diaza-bicyclo[2.2.2]octane; ethanol; caesium carbonate; potassium hydroxide; In N,N-dimethyl-formamide; toluene;