6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside

Base Information

Chemical Name:6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside
CAS No.:1200462-42-5
Molecular Formula:C₂₃H₂₇ClN₄O₇
Molecular Weight:506.943
Hs Code.:

Synonyms:6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside

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Chemical Property of 6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside

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Technology Process of 6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside

There total 10 articles about 6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1200462-38-9
9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

: 1200462-42-5
6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 1200461-13-7
(R/S)-1-(4-methoxy-2-nitrophenyl)-2-methyl-1-propanol

: 1201544-68-4
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-chloromethyl-7-deazapurine

: 1200462-42-5
6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside

Guidance literature:: (R/S)-1-(4-methoxy-2-nitrophenyl)-2-methyl-1-propanol; 9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-chloromethyl-7-deazapurine; at 108 ℃; for 0.5h; Neat (no solvent); Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
DOI:10.1002/anie.201106516

Reference yield:

: 1200462-11-8
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2‘-deoxyribofuranosyl]-6-chloro-7-hydroxymethyl-7-deazapurine

: 1200462-42-5
6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine-2‘-deoxyribonucleoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; p-toluenesulfonyl chloride / dichloromethane / 18 h / 20 °C

2.1: 0.5 h / 108 °C / Neat (no solvent); Inert atmosphere

2.2: 0.5 h / 0 - 20 °C

With dmap; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1002/anie.201106516