9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

Base Information

Chemical Name:9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine
CAS No.:1200462-38-9
Molecular Formula:C₃₅H₅₅ClN₄O₇Si₂
Molecular Weight:735.468
Hs Code.:

9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

Synonyms:9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

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Chemical Property of 9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

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Technology Process of 9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

There total 16 articles about 9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1200461-13-7
(R/S)-1-(4-methoxy-2-nitrophenyl)-2-methyl-1-propanol

: 1201544-68-4
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-chloromethyl-7-deazapurine

: 1200462-38-9
9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

: 9-[β-D-3′-O-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

Guidance literature:: In dichloromethane; at 108 ℃; for 0.5h;

Reference yield:

: 1200461-13-7
(R/S)-1-(4-methoxy-2-nitrophenyl)-2-methyl-1-propanol

: 1201544-68-4
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-chloromethyl-7-deazapurine

: 1200462-38-9
9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

Guidance literature:: at 108 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1200462-11-8
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2‘-deoxyribofuranosyl]-6-chloro-7-hydroxymethyl-7-deazapurine

: 1200462-38-9
9-[β-D-3′,5′-O-bis-(tert-butyldimethylsilyl)-2′-deoxyribofuranosyl]-6-chloro-7-[1-(4-methoxy-2-nitrophenyl)-2-methyl-propyloxy]methyl-7-deazapurine

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; p-toluenesulfonyl chloride / dichloromethane / 18 h / 20 °C

2: 0.5 h / 108 °C / Neat (no solvent); Inert atmosphere

With dmap; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1002/anie.201106516