11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-10-one

Base Information

• Chemical Name: 11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-10-one
• CAS No.: 113461-95-3
• Molecular Formula: C₃₃H₃₈N₂O₇
• Molecular Weight: 574.674

Synonyms:11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-10-one

Chemical Property of 11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-10-one

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Technology Process of 11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-10-one

There total 6 articles about 11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-benzyl-2-<(2,4,5-trimethoxy-3-methylphenyl)-methylene>-7,9,10-trimethoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine-11-carboxylic acid isopropyl ester (113461-91-9) → 11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-one (113461-95-3)

Guidance literature:

With sulfuric acid; trifluoroacetic acid; for 24h; Ambient temperature;

DOI:10.3987/R-1987-07-1765

Reference yield:

(Z)-4-benzyl-6-<(2,4,5-trimethoxy-3-methylphenyl)-methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione (113461-80-6) → 11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-one (113461-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 25 °C

2: 1.) lithium tri-tert-butoxyaluminium hydride, 2.) HCOOH / 1.) THF, 1 h, 2.) 60 deg C, 1 h

3: 4.7 g / conc.H₂SO₄, trifluoroacetic acid / 24 h / 25 °C

With dmap; formic acid; lithium tri(t-butoxy)aluminum hydride; sulfuric acid; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo00253a022

Reference yield:

(Z)-4-benzyl-1-<(benzyloxy)carbonyl>-6-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione (113461-83-9) → 11-Benzyl-3,4,6-trimethoxy-5-methyl-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-10-one (113461-95-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / lithium tri-tert-butylaluminium hydride / tetrahydrofuran / 1 h

2: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 25 °C

3: 1.) lithium tri-tert-butoxyaluminium hydride, 2.) HCOOH / 1.) THF, 1 h, 2.) 60 deg C, 1 h

4: 4.7 g / conc.H₂SO₄, trifluoroacetic acid / 24 h / 25 °C

With dmap; formic acid; lithium tri-tert-butoxyaluminum hydride; lithium tri(t-butoxy)aluminum hydride; sulfuric acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00253a022

upstream raw materials:

(E)-3-benzyl-2-<(2,4,5-trimethoxy-3-methylphenyl)-methylene>-7,9,10-trimethoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine-11-carboxylic acid isopropyl ester

(Z)-4-benzyl-1-<(isopropyloxy)carbonyl>-6-<2,4,5-trimethoxy-3-methylphenyl)methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione

4-Benzyl-2-hydroxy-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-3-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-1-carboxylic acid isopropyl ester

(Z)-4-benzyl-6-<(2,4,5-trimethoxy-3-methylphenyl)-methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione

Downstream raw materials:

(E)-3-benzyl-2-<(2,4,5-trimethoxy-3-methylphenyl)-methylene>-7,9,10-trimethoxy-8,11-dimethyl-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Butoxy-[(1S,9R,12R)-3,4,6-trimethoxy-5,13-dimethyl-12-(2,4,5-trimethoxy-3-methyl-benzyl)-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-11-yl]-acetic acid butyl ester

2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-3-(phthalimidoacetyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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