4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol

Base Information

Chemical Name:4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol
CAS No.:107244-80-4
Molecular Formula:C₂₂H₂₆ClN₃O
Molecular Weight:383.921
Hs Code.:

Synonyms:4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol

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Chemical Property of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol

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Technology Process of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol

There total 6 articles about 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 107244-71-3
4-amino-2-<(diethylamino)methyl>-6-ethylphenol

: 107244-80-4
4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol

Guidance literature:: In ethanol; for 1.5h; Heating;
DOI:10.1021/jm00388a027

Reference yield:

: 90-00-6
o-Hydroxyethylbenzene

: 107244-80-4
4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol

Guidance literature:: Multi-step reaction with 6 steps

1: 44 percent / aq. HCl, NaNO₂ / aq. ethanol / 5 h / 0 °C

2: H₂ / Ni (Ra) / methanol / 5.5 h / 2663.3 Torr

3: methanol; tetrahydrofuran / 0.5 h / Heating

4: 60 percent / ethanol / 48 h / Heating

5: 89 percent / 6N aq. HCl / 1 h / Heating

6: 81 percent / ethanol / 1.5 h / Heating

With hydrogenchloride; hydrogen; sodium nitrite; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00388a027

Reference yield:

: 107244-56-4
2-ethyl-4-(hydroxyimino)cyclohexa-2,5-dienone

: 107244-80-4
4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Ni (Ra) / methanol / 5.5 h / 2663.3 Torr

2: methanol; tetrahydrofuran / 0.5 h / Heating

3: 60 percent / ethanol / 48 h / Heating

4: 89 percent / 6N aq. HCl / 1 h / Heating

5: 81 percent / ethanol / 1.5 h / Heating

With hydrogenchloride; hydrogen; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00388a027