N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester

Base Information

• Chemical Name: N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester
• CAS No.: 5616-84-2
• Molecular Formula: C₂₉H₄₄N₄O₈
• Molecular Weight: 576.69
• Mol file: 5616-84-2.mol

Synonyms:N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester

Chemical Property of N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester

There total 6 articles about N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sarcosine tert-butyl ester (5616-81-9) → N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester (5616-84-2)

Guidance literature:

Multi-step reaction with 5 steps

1: DCC / CH₂Cl₂ / -10 °C

2: H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

3: DCC / CH₂Cl₂ / -10 °C

4: H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

5: DCC / CH₂Cl₂ / -10 °C

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/ja00085a002

Reference yield:

N-(benzyloxycarbonyl)prolylsarcosine tert-butyl ester (5616-82-0) → N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester (5616-84-2)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

2: DCC / CH₂Cl₂ / -10 °C

3: H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

4: DCC / CH₂Cl₂ / -10 °C

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/ja00085a002

Reference yield:

[Methyl-((S)-pyrrolidine-2-carbonyl)-amino]-acetic acid tert-butyl ester (63219-23-8) → N-(benzyloxycarbonyl)threonyl-D-valylprolylsarcosine tert-butyl ester (5616-84-2)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC / CH₂Cl₂ / -10 °C

2: H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr

3: DCC / CH₂Cl₂ / -10 °C

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/ja00085a002

upstream raw materials:

N-benzyloxycarbonyl-L-treonine

H-D-Val-Pro-Sar-OBu^t

sarcosine tert-butyl ester

[Methyl-((S)-pyrrolidine-2-carbonyl)-amino]-acetic acid tert-butyl ester

Downstream raw materials:

<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-L-threonyl-D-valyl-L-prolyl-sarcosyl-N-methyl-L-valine lactone