1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate

Base Information

Chemical Name:1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate
CAS No.:1400928-62-2
Molecular Formula:C₆H₈O₇*C₂₆H₃₂FN₃O₂
Molecular Weight:629.683
Hs Code.:

Synonyms:1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate

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Chemical Property of 1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate

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Technology Process of 1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate

There total 9 articles about 1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400928-48-4
C₂₆H₃₂FN₃O₂

: 77-92-9,906507-37-7
citric acid

: 1400928-62-2
1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate

Guidance literature:: In methanol; dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.07.021

Reference yield:

: 30897-90-6
(2-methyl-4-fluorophenyl)magnesium bromide

: 1400928-62-2
1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 6.25 h / 20 °C / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / toluene / 10 h / Inert atmosphere; Reflux

3: hydrogen; palladium(II) hydroxide / methanol / 48 h / 20 °C / 760.05 Torr

4: triethylamine / tetrahydrofuran / 48 h / 60 °C / Inert atmosphere

5: methanol; dichloromethane / 20 °C / Inert atmosphere

With hydrogen; palladium(II) hydroxide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; 4: |Michael Addition;
DOI:10.1016/j.ejmech.2012.07.021

Reference yield:

: 216311-09-0
1-benzyl-4-(4-fluoro-2-methylphenyl)piperidin-4-ol

: 1400928-62-2
1-{3-[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]propanoyl}-N,N-dimethylindoline-(2S)-2-carboxamide monocitrate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 10 h / Inert atmosphere; Reflux

2: hydrogen; palladium(II) hydroxide / methanol / 48 h / 20 °C / 760.05 Torr

3: triethylamine / tetrahydrofuran / 48 h / 60 °C / Inert atmosphere

4: methanol; dichloromethane / 20 °C / Inert atmosphere

With hydrogen; palladium(II) hydroxide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; 3: |Michael Addition;
DOI:10.1016/j.ejmech.2012.07.021