(6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione

Base Information

Chemical Name:(6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione
CAS No.:508183-95-7
Molecular Formula:C₂₅H₃₀N₂O₆
Molecular Weight:454.523
Hs Code.:

Synonyms:(6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione

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Technology Process of (6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione

There total 6 articles about (6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 108-24-7
acetic anhydride

: 508183-93-5
(3S,6R)-N,N'-bis(p-methoxybenzyl)-6-hydroxy-3-isopropylpiperazine-2,5-dione

: 508183-95-7
(6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione

Guidance literature:: With dmap; In pyridine; for 12h;
DOI:10.1039/b207457p

Reference yield:

: 127-09-3
sodium acetate

: 1027973-78-9
3-isopropyl-1,4-bis-(4-methoxy-benzyl)-5-trimethylsilanyloxy-3,4-dihydro-1H-pyrazin-2-one

: 508183-96-8
(6S,3S)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione

: 508183-95-7
(6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione

Guidance literature:: 3-isopropyl-1,4-bis-(4-methoxy-benzyl)-5-trimethylsilanyloxy-3,4-dihydro-1H-pyrazin-2-one; With [bis(acetoxy)iodo]benzene; In tetrahydrofuran; at -78 ℃; for 2h;

sodium acetate; In tetrahydrofuran; at -78 - 20 ℃; for 15h; Further stages.;
DOI:10.1039/b207457p

Reference yield:

: 205517-34-6
(3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

: 508183-95-7
(6S,3R)-N,N'-bis(p-methoxybenzyl)-3-acetoxy-6-isopropylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

2.1: (diacetoxyiodo)benzene / tetrahydrofuran / 2 h / -78 °C

2.2: tetrahydrofuran / 15 h / -78 - 20 °C

With [bis(acetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1039/b207457p