N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide

Base Information

Chemical Name:N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide
CAS No.:1422025-79-3
Molecular Formula:C₂₁H₂₇N₃O₅S
Molecular Weight:433.528
Hs Code.:

Synonyms:N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide

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Chemical Property of N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide

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Technology Process of N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide

There total 4 articles about N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1422027-25-5
1-(2-nitrophenylsulfonamido)cyclobutanecarboxylic acid

: 10523-68-9
adamantan-2-amine hydrochloride

: 1422025-79-3
N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1422025-79-3
N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 12 h / 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C

2.2: pH 2 - 3

3.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

With lithium hydroxide monohydrate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1422027-24-4
methyl 1-(2-nitrophenylsulfonamido)cyclobutanecarboxylate

: 1422025-79-3
N-(adamantane-2-yl)-1-(2-nitrophenylsulfonamido)cyclobutanecarboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C

1.2: pH 2 - 3

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

With lithium hydroxide monohydrate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;