4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester

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Chemical Name:4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester
CAS No.:256419-31-5
Molecular Formula:C₂₆H₃₆N₂O₆
Molecular Weight:472.582
Hs Code.:

Synonyms:4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester

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Chemical Property of 4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester

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Technology Process of 4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester

There total 1 articles about 4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2393-23-9
4-methoxy-benzylamine

: 4(R)-((N-t-butoxycarbonyl)amino)-2(R),3(S)-epoxy-5-phenyl-pentanoic acid ethyl ester

: 256419-31-5
4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: In tetrahydrofuran; ethanol; at 60 ℃; for 24h;
DOI:10.1007/PL00010189

Reference yield: 86.0%

: 256419-31-5
4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester

: 256419-34-8
4(R)-((N-t-butoxycarbonyl)amino)-2(R)-(4-methoxybenzylamino)-5-phenyl-pentane-1,3(S)-diol

Guidance literature:: With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 24h;
DOI:10.1007/PL00010189

Reference yield:

: 256419-31-5
4(R)-((N-t-butoxycarbonyl)amino)-3(S)-hydroxy-2(S)-(4-methoxy-benzylamino)-5-phenyl-pentanoic acid ethyl ester

: 256419-40-6
(4R,5S,6R)-4-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-hydroxymethyl-1-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / NaBH₄; LiCl / ethanol; tetrahydrofuran / 24 h / 20 °C

2: HCl / CH₂Cl₂; ethyl acetate / 2 h

3: imidazole / CH₂Cl₂ / 12 h / 20 °C

4: CH₂Cl₂ / 0.5 h

5: 96 percent / 40 percent HF / acetonitrile / 24 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; hydrogen fluoride; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; acetonitrile; 1: Reduction / 2: deprotection / 3: silylation / 4: cyclocondensation / 5: desilylation;
DOI:10.1007/PL00010189