4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide

Base Information

• Chemical Name: 4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide
• CAS No.: 1578484-76-0
• Molecular Formula: C₁₆H₁₄N₂O₅S
• Molecular Weight: 346.364
• Mol file: 1578484-76-0.mol

Synonyms:4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide

Chemical Property of 4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide

There total 1 articles about 4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

phthalic anhydride (85-44-9) + 4-amino-3-hydroxy-N,N-dimethylbenzenesulfonamide (41608-75-7) → 4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide (1578484-76-0)

Guidance literature:

With acetic acid; at 120 ℃; for 1h; Microwave irradiation;

Reference yield: 58.0%

4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide (1578484-76-0) + methyl iodide (74-88-4) → 4-(1,3-dioxoisoindolin-2-yl)-3-methoxy-N,N-dimethylbenzenesulfonamide (1578484-75-9)

Guidance literature:

With potassium carbonate; In ethanol; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

4-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-N,N-dimethylbenzenesulfonamide (1578484-76-0) → 4-amino-3-methoxy-N,N-dimethylbenzenesulfonamide (41608-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / 1 h / 100 °C / Microwave irradiation

2: hydrazine hydrate / methanol / 2 h / 20 °C

With hydrazine hydrate; potassium carbonate; In methanol; ethanol;

upstream raw materials:

phthalic anhydride

4-amino-3-hydroxy-N,N-dimethylbenzenesulfonamide

Downstream raw materials:

4-(1,3-dioxoisoindolin-2-yl)-3-methoxy-N,N-dimethylbenzenesulfonamide

4-amino-3-methoxy-N,N-dimethylbenzenesulfonamide