methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate

Base Information

Chemical Name:methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate
CAS No.:1431322-44-9
Molecular Formula:C₁₅H₁₀F₃N₃O₂
Molecular Weight:321.259
Hs Code.:

Synonyms:methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate

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Chemical Property of methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate

Chemical Property:

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Technology Process of methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate

There total 4 articles about methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431322-43-8
methyl 6-chloro-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate

: 1431322-44-9
methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate

Guidance literature:: With palladium on activated charcoal; hydrogen; triethylamine; In ethyl acetate; at 20 ℃; for 4h; under 760.051 Torr;

Reference yield:

: 1431322-42-7
8-bromo-6-chloro-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine

: 1431322-44-9
methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C / 3040.2 Torr

2: triethylamine; palladium on activated charcoal; hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 54109-16-9
2-(trifluoromethyl)phenacyl bromide

: 1431322-44-9
methyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 24 h / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C / 3040.2 Torr

3: triethylamine; palladium on activated charcoal; hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile;