N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide

Base Information

Chemical Name:N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide
CAS No.:1431321-35-5
Molecular Formula:C₁₇H₁₀F₃N₅OS
Molecular Weight:389.361
Hs Code.:

Synonyms:N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide

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Technology Process of N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide

There total 6 articles about N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 96-50-4
2-thiazolylamine

: 1431322-45-0
2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxylic acid

: 1431321-35-5
N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: 54109-16-9
2-(trifluoromethyl)phenacyl bromide

: 1431321-35-5
N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 24 h / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C / 3040.2 Torr

3: triethylamine; palladium on activated charcoal; hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr

4: sodium hydroxide / methanol; water

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 6 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1431322-42-7
8-bromo-6-chloro-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine

: 1431321-35-5
N-(thiazol-2-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C / 3040.2 Torr

2: triethylamine; palladium on activated charcoal; hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr

3: sodium hydroxide / methanol; water

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 6 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;