p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Base Information

Chemical Name:p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside
CAS No.:938060-83-4
Molecular Formula:C₄₈H₄₇NO₁₃
Molecular Weight:845.9
Hs Code.:

Synonyms:p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

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Chemical Property of p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

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Technology Process of p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

There total 7 articles about p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 165199-19-9
p-methoxyphenyl 4,6-O-benzylidene-3-O-tert-butyldiphenylsilyl-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

: 938060-83-4
p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetlet.2007.02.108

Reference yield:

: 129575-89-9
p-methoxyphenyl 3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

: 938060-83-4
p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / iodine; silver triflate; 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / -78 - 20 °C

2: 81 percent / triflic anhydride; dimethyl disulfide; 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 1 h / 0 - 20 °C

3: 60 percent / TBAF / tetrahydrofuran; dimethylformamide / 20 °C

With 2,6-di-tert-butyl-4-methylpyridine; Dimethyldisulphide; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; iodine; silver trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2007.06.026

Reference yield:

: C₃₃H₄₀O₅SSi

: 938060-83-4
p-methoxyphenyl 4,6-O-benzylidene-β-D-mannopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / (Ph₃P)3RhCl / tetrahydrofuran / Heating

1.2: I₂; DTBMP / AgOTf / CH₂Cl₂ / -78 - 20 °C

2.1: 29 percent / Me₂S; Tf₂O; DBTMP / CH₂Cl₂ / 0 - 20 °C

3.1: 60 percent / TBAF / tetrahydrofuran / 20 °C

With n-butyllithium; dimethylsulfide; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; Wilkinson's catalyst; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2007.02.108