Mosapride citrate dihydrate

Base Information

• Chemical Name: Mosapride citrate dihydrate
• CAS No.: 156925-25-6
• Molecular Formula: C₆H₈O₇*C₂₁H₂₅ClFN₃O₃
• Molecular Weight: 614.025
• Hs Code.: 2934999090
• European Community (EC) Number: 633-897-8,811-513-1
• UNII: 73033I28Y6
• DSSTox Substance ID: DTXSID10979874
• Wikidata: Q27266110
• Mol file: 156925-25-6.mol

Synonyms:Mosapride citrate dihydrate;156925-25-6;636582-62-2;Mosapride citrate hydrate;Mosapride citrate salt dihydrate;Mosapride (citrate dihydrate);UNII-73033I28Y6;636582-62-2 (citrate hydrate);TAK-370 citrate;AS-4370 citrate;4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl ]-2-morpholinyl]methyl]benzamide citrate dihydrate;73033I28Y6;4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate dihydrate;4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide;2-hydroxypropane-1,2,3-tricarboxylic acid;dihydrate;4-Amino-5-Chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate hydrate(1:1:2);Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, (S)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (9CI);Gasmotin (TN);Mosapride Citrate,(S);CHEBI:31867;HY-B0189B;DTXSID10979874;Mosapride citrate hydrate (JP17);BCP12161;morpholin-2-yl)methyl)benzamide 2-;AKOS015911959;KS-1180;MOSAPRIDE CITRATE HYDRATE [JAN];GR 107719 B;GR-107719-B;PD040832;CS-0088736;FT-0600403;FT-0672539;hydroxypropane-1,2,3-tricarboxylate dihydrate;D01994;W-204238;4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl);Q27266110;2-Hydroxypropane-1,2,3-tricarboxylic acid--4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzene-1-carboximidic acid--water (1/1/2);BENZAMIDE, 4-AMINO-5-CHLORO-2-ETHOXY-N-((4-((4-FLUOROPHENYL)METHYL)-2-MORPHOLINYL)METHYL)-, 2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE (1:1), DIHYDRATE;BENZAMIDE, 4-AMINO-5-CHLORO-2-ETHOXY-N-((4-((4-FLUOROPHENYL)METHYL)-2-MORPHOLINYL)METHYL)-, 2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE, HYDRATE (1:1:2)

Chemical Property of Mosapride citrate dihydrate

Chemical Property:

• Appearance/Colour: white powder
• PSA: 227.41000
• LogP: 2.62370
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 12
• Exact Mass: 649.2049795
• Heavy Atom Count: 44
• Complexity: 749

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O.O
• Uses: Carbamazepine metabolite

Technology Process of Mosapride citrate dihydrate

There total 19 articles about Mosapride citrate dihydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

mosapride (112885-41-3) + citric acid (77-92-9,906507-37-7) → mosapride citrate (112885-42-4,156925-25-6)

Guidance literature:

In ethanol; water; at 70 - 75 ℃; for 0.5h; Temperature;

Reference yield: 88.7%

4-acetylamino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide (112885-34-4) + citric acid (77-92-9,906507-37-7) → mosapride citrate (112885-42-4,156925-25-6)

Guidance literature:

In methanol; water; at 50 - 65 ℃; Temperature;

Reference yield: 88.0%

(RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluoro-benzyl)-2-morpholinyl]-methyl}-benzamide dihydrochloride + citric acid (77-92-9,906507-37-7) → mosapride citrate (112885-42-4,156925-25-6)

Guidance literature:

(RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluoro-benzyl)-2-morpholinyl]-methyl}-benzamide dihydrochloride; With sodium hydroxide; In dichloromethane; water; for 0.5h; Heating / reflux;

citric acid; In water; at 0 ℃; for 0.5h; Heating / reflux;

upstream raw materials:

mosapride

(RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluoro-benzyl)-2-morpholinyl]-methyl}-benzamide trifluoroacetate

citric acid

sodium p-aminosalicylate

Refernces

• 1、 -. "Synthesis method of mosapride citrate". Paragraph 0050-0051. . Retrieved 2020/07/15.
• 2、 -. "4-amino-5-chloro-2-ethoxy-N- "[ 4-(4-Flurobenzyl)-2-morphorinyl] methyl" phenylbenzamide hydroxycitric salt 2 hydrate production method". Paragraph 0065; 0069; 0071. . Retrieved 2016/10/08.