5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole

Base Information

• Chemical Name: 5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole
• CAS No.: 1172135-98-6
• Molecular Formula: C₁₅H₁₄ClN₃O₂S₂
• Molecular Weight: 367.88

Synonyms:5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole

Chemical Property of 5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole

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Technology Process of 5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole

There total 1 articles about 5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acetylacetone (123-54-6,81235-32-7) + 5-chloro-2-hydrazino-4-p-tolylsulfonyl-1,3-thiazole (297142-57-5) → 5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole (1172135-98-6)

Guidance literature:

With acetic acid; In ethanol; for 10h; Reflux;

DOI:10.1134/S1070363208110248

Reference yield: 87.0%

5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole (1172135-98-6) → 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(p-tolylsulfonyl)-1,3-thiazole-5-thiol (1172136-02-5)

Guidance literature:

5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole; With sodium hydrogensulfide; In methanol; at 20 - 25 ℃; for 20h;

With hydrogenchloride; In water;

DOI:10.1134/S1070363208110248

Reference yield: 84.0%

5-chloro-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(ptolylsulfonyl)-1,3-thiazole (1172135-98-6) + p-Chlorothiophenol (106-54-7) → 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(p-tolylsulfonyl)-5-(4-chlorophenylsulfanyl)-1,3-thiazole (1172136-01-4)

Guidance literature:

With triethylamine; In ethanol; for 15h; Reflux;

DOI:10.1134/S1070363208110248

upstream raw materials:

acetylacetone

5-chloro-2-hydrazino-4-p-tolylsulfonyl-1,3-thiazole

Downstream raw materials:

2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-(pyrrolidin-1-yl)-4-(p-tolylsulfonyl)-1,3-thiazole

2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-morpholino-4-(p-tolylsulfonyl)-1,3-thiazoles

2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-(p-tolylsulfonyl)-1,3-thiazole-5-thiol

2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-(p-tolyloxy)-4-(p-tolylsulfonyl)-1,3-thiazole

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