4-(Triethylsilyl)-3-butyn-1-ol

Base Information

• Chemical Name: 4-(Triethylsilyl)-3-butyn-1-ol
• CAS No.: 160194-29-6
• Molecular Formula: C10H20OSi
• Molecular Weight: 184.354
• Hs Code.: 2931900090
• DSSTox Substance ID: DTXSID90375299
• Nikkaji Number: J980.393I
• Wikidata: Q72510680
• Mol file: 160194-29-6.mol

Synonyms:160194-29-6;4-(Triethylsilyl)-3-butyn-1-ol;4-(triethylsilyl)but-3-yn-1-ol;4-triethylsilylbut-3-yn-1-ol;3-Butyn-1-ol, 4-(triethylsilyl)-;4-triethylsilanyl-but-3-yn-1-ol;SCHEMBL893000;4-triethylsilyl-3-butyn-1-ol;TIMTEC-BB SBB009039;DTXSID90375299;WAVVVDUELKMQAZ-UHFFFAOYSA-N;4-(triethylsilyl)but-3-in-1-ol;4-(Triethylsilyl)-3-butyne-1-ol;AMY42148;BCP18461;MFCD00190219;AKOS006343711;CS-W016993;BS-52256;FT-0600777;EN300-302075;S17618;A810122

Chemical Property of 4-(Triethylsilyl)-3-butyn-1-ol

Chemical Property:

• Vapor Pressure: 0.0187mmHg at 25°C
• Refractive Index: 1.4686
• Boiling Point: 224.2 °C at 760 mmHg
• PKA: 14.46±0.10(Predicted)
• Flash Point: 89.4 °C
• PSA: 20.23000
• Density: 0.877 g/cm³
• LogP: 2.41990
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 184.128341792
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

98%Min ^*data from raw suppliers

TRIETHYLSILYL-3-BUTYN-1OL ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC[Si](CC)(CC)C#CCCO

Technology Process of 4-(Triethylsilyl)-3-butyn-1-ol

There total 5 articles about 4-(Triethylsilyl)-3-butyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-triethylsilanyl-4-(triethylsilanyloxy)but-1-yne (160194-28-5) → 4-(1,1,1-trimethylsilyl)-3-butyn-1-ol (160194-29-6)

Guidance literature:

With hydrogenchloride; water; In methanol; at 20 ℃; for 4h;

Reference yield: 91.0%

4-(1,1,1-trimethylsilyl)-3-butynyl trityl ether → 4-(1,1,1-trimethylsilyl)-3-butyn-1-ol (160194-29-6)

Guidance literature:

4-(1,1,1-trimethylsilyl)-3-butynyl trityl ether; With boron trichloride; In dichloromethane; at -30 ℃; for 0.5h;

With methanol; Further stages.;

DOI:10.1021/jo9913255

Reference yield: 84.0%

triethylsilane (617-86-7) + 3-Butyn-1-ol (927-74-2) → 4-(1,1,1-trimethylsilyl)-3-butyn-1-ol (160194-29-6)

Guidance literature:

With Au₉₇Ag₃; oxygen; In toluene; at 80 ℃; for 18h; chemoselective reaction;

DOI:10.1002/chem.201803874

upstream raw materials:

1-triethylsilanyl-4-(triethylsilanyloxy)but-1-yne

triethylsilyl chloride

3-Butyn-1-ol

triethylsilane

Downstream raw materials:

6-benzyloxy-3-(2-hydroxy-ethyl)-7-methyl-2-triethylsilanyl-1H-indole-4-carbonitrile

N-(2-(5-chloro-7-fluoro-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide

N-(2-(5-chloro-2-(triethylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide

Refernces

• 1、 Wennekes, Tom,Van Den Berg, Richard J. B. H. N.,Boltje, Thomas J.,Donker-Koopman, Wilma E.,Kuijper, Bastiaan,Van Der Marel, Gijsbert A.,Strijland, Anneke,Verhagen, Carlo P.,Aerts, Johannes M. F. G.,Overkleeft, Herman S.. "Synthesis and evaluation of lipophilic Aza-C-glycosides as inhibitors of glucosylceramide metabolism". experimental part. p. 1258 - 1283. Retrieved 2010/05/19.
• 2、 Jones, Graham B.,Hynd, George,Wright, Justin M.,Sharma, Anu. "On the Selective Deprotection of Trityl Ethers". . p. 263 - 265. Retrieved 2007/10/03.