Technology Process of methyl 2-cyclopropyl-2-phenylpropionate
There total 5 articles about methyl 2-cyclopropyl-2-phenylpropionate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 50 percent / silver nitrate, sodium hydroxide / ethanol; H2O / 24 h / Ambient temperature
2: oxalyl chloride / benzene / 3 h / Ambient temperature
3: pyridine / 3 h / 20 °C
4: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C
With
pyridine; sodium hydroxide; oxalyl dichloride; silver nitrate; lithium diisopropyl amide;
In
ethanol; water; benzene;
DOI:10.1021/jo00282a020
- Guidance literature:
-
Multi-step reaction with 3 steps
1: oxalyl chloride / benzene / 3 h / Ambient temperature
2: pyridine / 3 h / 20 °C
3: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C
With
pyridine; oxalyl dichloride; lithium diisopropyl amide;
In
benzene;
DOI:10.1021/jo00282a020
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) potassium hydroxide, 2.) 1 N hydrochloric acid / 1.) ethanol, water, RT, 20 h
2: 50 percent / silver nitrate, sodium hydroxide / ethanol; H2O / 24 h / Ambient temperature
3: oxalyl chloride / benzene / 3 h / Ambient temperature
4: pyridine / 3 h / 20 °C
5: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C
With
pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; oxalyl dichloride; silver nitrate; lithium diisopropyl amide;
In
ethanol; water; benzene;
DOI:10.1021/jo00282a020
