1-Benzyl 3-methyl piperazine-1,3-dicarboxylate

Base Information

Chemical Name:1-Benzyl 3-methyl piperazine-1,3-dicarboxylate
CAS No.:129799-11-7
Molecular Formula:C14H18N2O4
Molecular Weight:278.308
Hs Code.:2933599090
European Community (EC) Number:672-437-0
DSSTox Substance ID:DTXSID90373871
Mol file:129799-11-7.mol

Synonyms:129799-11-7;1-benzyl 3-methyl piperazine-1,3-dicarboxylate;N-4-Cbz-piperazine-2-carboxylate methyl ester;methyl 4-cbz-piperazine-2-carboxylate;4-Cbz-piperazine-2-carboxylate methyl ester;MFCD03001724;piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester;1-O-benzyl 3-O-methyl piperazine-1,3-dicarboxylate;1,3-Piperazinedicarboxylic acid, 3-methyl 1-(phenylmethyl) ester;methyl 4-(benzyloxycarbonyl)piperazine-2-carboxylate;(S)-4-N-Cbz-piperazine-2-carboxylicacidmethylester;Methyl-4-CBZ piperazine-2-carboxylate;4-n-cbz-piperazine-2-carboxylic acid methyl ester;SCHEMBL2680992;DTXSID90373871;FYKXWBBQYZXPFB-UHFFFAOYSA-N;AKOS005258750;AB19911;AB19914;CS-W002984;DS-0781;methyl n-4-cbz-piperazine-2-carboxylate;AC-14343;SY017973;3-(3-methoxyphenyl)propyl methanesulfonate;1-benzyloxycarbonyl-3-carbomethoxypiperazine;AM20020377;FT-0600861;FT-0655221;FT-0655353;1-benzyl3-methylpiperazine-1,3-dicarboxylate;A12960;N-4-Cbz-piperazine-2-carboxylate?methyl?ester;methyl 4-benzyloxycarbonylpiperazine-2-carboxylate;n-4-cbz-piperazine-2-carboxylate methyl ester, AldrichCPR;(R)-1-benzyl 3-methyl piperazine-1,3-dicarboxylate;(R)-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER

Suppliers and Price of 1-Benzyl 3-methyl piperazine-1,3-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Benzyl3-Methylpiperazine-1,3-dicarboxylate
1g
$ 175.00

Matrix Scientific
1-Benzyl 3-methyl piperazine-1,3-dicarboxylate 95+%
10g
$ 1000.00

Matrix Scientific
1-Benzyl 3-methyl piperazine-1,3-dicarboxylate 95+%
1g
$ 231.00

Matrix Scientific
1-Benzyl 3-methyl piperazine-1,3-dicarboxylate 95+%
5g
$ 700.00

Crysdot
1-Benzyl3-methylpiperazine-1,3-dicarboxylate 95+%
25g
$ 743.00

Crysdot
1-Benzyl3-methylpiperazine-1,3-dicarboxylate 95+%
10g
$ 371.00

Chemenu
1-Benzyl3-methylpiperazine-1,3-dicarboxylate 95%+
25g
$ 1344.00

Chemenu
1-Benzyl3-methylpiperazine-1,3-dicarboxylate 95%+
10g
$ 839.00

Chemenu
1-Benzyl3-methylpiperazine-1,3-dicarboxylate 95%+
1g
$ 105.00

Chemenu
1-Benzyl3-methylpiperazine-1,3-dicarboxylate 95%+
5g
$ 377.00

Total 39 raw suppliers

Chemical Property of 1-Benzyl 3-methyl piperazine-1,3-dicarboxylate

Chemical Property:

Vapor Pressure:1.88E-09mmHg at 25°C
Refractive Index:1.569
Boiling Point:406.5 °C at 760 mmHg
PKA:6.43±0.40(Predicted)
Flash Point:199.7 °C
PSA：67.87000
Density:1.212 g/cm³
LogP:1.03670
Storage Temp.:2-8°C(protect from light)
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:278.12665706
Heavy Atom Count:20
Complexity:342

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl3-Methylpiperazine-1,3-dicarboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1CN(CCN1)C(=O)OCC2=CC=CC=C2

Technology Process of 1-Benzyl 3-methyl piperazine-1,3-dicarboxylate

There total 4 articles about 1-Benzyl 3-methyl piperazine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 171504-98-6
O₁,O₄-di-tert-butyl O₂-methyl piperazine-1,2,4-tricarboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 129799-11-7
1-benzyl 3-methyl piperazine-1,3-dicarboxylate

Guidance literature:: O₁,O₄-di-tert-butyl O₂-methyl piperazine-1,2,4-tricarboxylate; With hydrogenchloride; In methanol; at 20 ℃;

benzyl chloroformate; With triethylamine; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

: 2758-98-7
2-methoxycarbonyltetrahydropyrazine

: 501-53-1,94274-21-2
benzyl chloroformate

: 129799-11-7
1-benzyl 3-methyl piperazine-1,3-dicarboxylate

Guidance literature:: In sodium hydrogencarbonate;

Reference yield:

: 181955-79-3
N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid

: 129799-11-7
1-benzyl 3-methyl piperazine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C / Cooling with ice

2.1: hydrogenchloride / methanol / 20 °C

2.2: 3 h / 20 °C / Cooling with ice

With hydrogenchloride; potassium carbonate; In methanol; N,N-dimethyl-formamide;