N-1-BOC-4-CBZ-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: N-1-BOC-4-CBZ-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER
• CAS No.: 129799-14-0
• Molecular Formula: C19H26N2O6
• Molecular Weight: 378.425
• Hs Code.: 2933599090
• Mol file: 129799-14-0.mol

Synonyms:N-1-BOC-4-CBZ-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER;4-Benzyl 1-tert-butyl 2-Methyl piperazine-1,2,4-tricarboxylate

Chemical Property of N-1-BOC-4-CBZ-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 85.38000
• LogP: 2.29330
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-1-Boc-4-Cbz-2-PiperazinecarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-1-BOC-4-CBZ-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER

There total 7 articles about N-1-BOC-4-CBZ-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (149057-19-2) + methyl iodide (74-88-4) → 4-benzyl 1-(tert-butyl) 2-methyl piperazine-1,2,4-tricarboxylate (129799-14-0,1313278-42-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield: 85.0%

benzyl chloroformate (501-53-1,94274-21-2) + piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (129799-15-1) → 4-benzyl 1-(tert-butyl) 2-methyl piperazine-1,2,4-tricarboxylate (129799-14-0,1313278-42-0)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1039/c5cc03002a

Reference yield:

1-benzyl 3-methyl piperazine-1,3-dicarboxylate (129799-11-7) + di-tert-butyl dicarbonate (24424-99-5) → 4-benzyl 1-(tert-butyl) 2-methyl piperazine-1,2,4-tricarboxylate (129799-14-0,1313278-42-0)

Guidance literature:

With triethylamine; In dichloromethane; water;

upstream raw materials:

1-benzyl 3-methyl piperazine-1,3-dicarboxylate

di-tert-butyl dicarbonate

4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

methyl iodide

Refernces

• 1、 -. "Pan-Tropic Entry Inhibitors". Page/Page column 46. . Retrieved 2019/10/15.
• 2、 Foley, Daniel J.,Doveston, Richard G.,Churcher, Ian,Nelson, Adam,Marsden, Stephen P.. "A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids". supporting information. p. 11174 - 11177. Retrieved 2015/07/07.