(S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

Base Information

Chemical Name:(S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea
CAS No.:1333108-23-8
Molecular Formula:C₂₅H₂₆N₆O₂
Molecular Weight:442.52
Hs Code.:

Synonyms:(S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

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Chemical Property of (S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

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Technology Process of (S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

There total 3 articles about (S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1333108-99-8
(S)-1-(4-(6-chloro-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

: 138642-62-3
2-Cyanophenylboronic acid

: 1333108-23-8
(S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

Guidance literature:: With caesium carbonate; trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex; In 1,4-dioxane; water; at 110 ℃; for 0.666667h; Microwave irradiation;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1333108-23-8
(S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.67 h / 110 °C / Microwave irradiation

2.2: pH 7 - 10

3.1: caesium carbonate / trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex / 1,4-dioxane; water / 0.67 h / 110 °C / Microwave irradiation

With caesium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1333108-98-7
(3S)-4-(4,6-dichloropyrimidin-2-yl)-3-methylmorpholine

: 1333108-23-8
(S)-1-(4-(6-(2-cyanophenyl)-2-(3-methylmorpholino)pyrimidin-4-yl)phenyl)-3-ethylurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.67 h / 110 °C / Microwave irradiation

1.2: pH 7 - 10

2.1: caesium carbonate / trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex / 1,4-dioxane; water / 0.67 h / 110 °C / Microwave irradiation

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trans-bis(triphenylphosphine)palladium(II) dichloride dichloromethane complex; In 1,4-dioxane; water;