(1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol

Base Information

Chemical Name:(1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol
CAS No.:728041-37-0
Molecular Formula:C₃₇H₃₉N₃O₃
Molecular Weight:573.735
Hs Code.:

Synonyms:(1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol

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Chemical Property of (1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol

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Technology Process of (1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol

There total 1 articles about (1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123054-12-6,123808-74-2,136370-73-5,111060-64-1
(2S)-N,N-dibenzylphenylalaninal

: 85059-48-9
2-isocyano-1-morpholin-4-yl-3-phenylpropan-1-one

: (1R,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol

: 728041-37-0
(1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol

Guidance literature:: With lithium bromide; In toluene; at 70 ℃;
DOI:10.1016/j.tet.2004.03.084

Reference yield: 86.0%

: 728041-37-0
(1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol

: (2S,3S)-N-(1-Benzyl-2-morpholin-4-yl-2-oxo-ethyl)-3-dibenzylamino-2-hydroxy-4-phenyl-butyramide

Guidance literature:: With water; trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2004.03.084

Reference yield:

: 728041-37-0
(1S,2S)-1-(4-Benzyl-5-morpholin-4-yl-oxazol-2-yl)-2-dibenzylamino-3-phenyl-propan-1-ol

: (4S,5S)-4-Benzyl-2-oxo-oxazolidine-5-carboxylic acid (1-benzyl-2-morpholin-4-yl-2-oxo-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / CF₃COOH; H₂O / tetrahydrofuran / 0.5 h / 20 °C

2: 97 percent / H₂ / Pd(OH)2 / methanol / 3 h

3: 78 percent / pyridine / CH₂Cl₂ / -70 - 20 °C

With pyridine; water; hydrogen; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2004.03.084