85059-48-9

Basic information

• Product Name: 2-ISOCYANO-3-PHENYL-PROPIONIC ACID MORPHOLINAMIDE
• Synonyms: 2-ISOCYANO-3-PHENYL-PROPIONIC ACID MORPHOLINAMIDE;2-isocyano-1-morpholin-4-yl-3-phenylpropan-1-one
• CAS NO: 85059-48-9
• Molecular Formula: C₁₄H₁₆N₂O₂
• Molecular Weight: 244.29
• Mol File: 85059-48-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-ISOCYANO-3-PHENYL-PROPIONIC ACID MORPHOLINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOCYANO-3-PHENYL-PROPIONIC ACID MORPHOLINAMIDE(85059-48-9)
• EPA Substance Registry System: 2-ISOCYANO-3-PHENYL-PROPIONIC ACID MORPHOLINAMIDE(85059-48-9)

Safety Data

• Hazardous Substances Data: 85059-48-9(Hazardous Substances Data)

Upstream product

• 120301-87-3 N-(1-benzyl-2-morpholin-4-yl-2-oxo-ethyl)formamide 
• 67434-29-1 isocyanoacetylmorpholine 
• 150-30-1 Phenylalanine 
• 100-39-0 benzyl bromide 
• 71921-02-3 2-benzyl-2-formamidoacetic acid methyl ester 

Downstream Products

• 336105-97-6 6-[1-(4-benzyl-5-morpholin-4-yl-oxazol-2-yl)-heptylamino]-hexanoic acid methyl ester 
• 336105-90-9 [1-(4-benzyl-5-morpholin-4-yl-oxazol-2-yl)-heptyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine 
• 336105-92-1 [1-(4-benzyl-5-morpholin-4-yl-oxazol-2-yl)-heptyl]-(3-methyl-benzyl)-amine 
• 336105-96-5 [(4-benzyl-5-morpholin-4-yl-oxazol-2-yl)-cyclooctyl-methyl]-(4-fluoro-benzyl)-amine 
• 651021-97-5 6-benzyl-7-hexyl-2-morpholin-4-yl-4,5,6,7-tetrahydro-furo[2,3-c]pyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Divergent Synthesis of Enantioenriched β-Functional Amines via Desymmetrization of meso-Aziridines with Isocyanides

A highly enantioselective ring-opening desymmetrization of meso-aziridines with isocyanides was achieved in the presence of a chiral N,N′-dioxide/Mg(OTf)2 complex. The in situ generated chiral 1,4-zwitterionic intermediates were successfully trapped by intramolecular oxygen- and carbon-based nucleophiles or exogenous H2O and TMSN3, enabling a collective synthesis of various chiral vicinal amino-oxazoles, spiroindolines, β-amino amides, and tetrazole derivative in moderate to high yields with excellent enantioselectivities.

Substituted Oxazole Compounds with Analgesic Activity

Substituted oxazole derivatives corresponding to formula 1: a method for producing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhoea, pruritus, a

Synthesis of α-isocyano-α-alkyl(aryl)acetamides and their use in the multicomponent synthesis of 5-aminooxazole, pyrrolo[3,4-a]pyridin-5-one and 4,5,6,7-tetrahydrofuro[2,3-c]pyridine

α-Isocyano-β-phenylpropionamide 1 is synthesized from the corresponding amino acid in excellent yield. The unique reactivity of this bifunctional compound is exploited for the development of novel multicomponent synthesis of 5-aminooxazole 6, pyrrolo[3,4-