ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate

Base Information

Chemical Name:ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate
CAS No.:1318126-80-5
Molecular Formula:C₂₀H₁₉N₃O₃S
Molecular Weight:381.455
Hs Code.:

Synonyms:ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate

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Chemical Property of ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate

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Technology Process of ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate

There total 8 articles about ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1318132-90-9
ethyl 4-methyl-3-((4-(methylsulfinyl)thieno[3,2-d]pyrimidin-7-yl)ethynyl)benzoate

: 141-43-5
ethanolamine

: 1318126-80-5
ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 120 ℃; for 8h;

Reference yield:

: 16234-10-9
3H-thieno[3,2-d]pyrimidin-4-one

: 1318126-80-5
ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: bromine / acetic acid / 10 h / 120 °C / closed reactor

2: trichlorophosphate / 3 h / 150 °C

3: tetrahydrofuran / 15 h / 0 °C

4: N-cyclohexyl-cyclohexanamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 14 h / 80 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 16 h / 20 °C

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C

8: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 8 h / 120 °C

With tetrabutyl ammonium fluoride; bromine; N-ethyl-N,N-diisopropylamine; N-cyclohexyl-cyclohexanamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 31169-27-4
7-bromo-4-chlorothieno[3,2-d]pyrimidine

: 1318126-80-5
ethyl 3-((4-(2-hydroxyethylamino)thieno[3,2-d]pyrimidin-7-yl)ethynyl)-4-methyl benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 15 h / 0 °C

2: N-cyclohexyl-cyclohexanamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 14 h / 80 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C

6: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 8 h / 120 °C

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; N-cyclohexyl-cyclohexanamine; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;