2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate)

Base Information

Chemical Name:2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate)
CAS No.:1443300-18-2
Molecular Formula:C₂₅H₃₂N₂O₁₀
Molecular Weight:520.536
Hs Code.:

Synonyms:2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate)

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Chemical Property of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate)

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Technology Process of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate)

There total 11 articles about 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 2544-06-1
3-Methoxypropionic acid

: 1443052-79-6
ethyl 5-(dimethylcarbamoyl)-3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 1443300-18-2
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate)

Guidance literature:: 3-Methoxypropionic acid; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at -15 ℃; for 0.333333h;

ethyl 5-(dimethylcarbamoyl)-3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate; In dichloromethane; at -15 - 20 ℃; for 18h;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1443300-18-2
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate)

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate; sodium iodide / water / 3 h / 90 °C

2.1: water; sodium hydroxide / tetrahydrofuran; ethanol / 3 h / 40 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C

5.1: sodium ethanolate / ethanol / 1.5 h / 85 °C

6.1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / 0.33 h / -15 °C

6.2: 18 h / -15 - 20 °C

With 4-methyl-morpholine; water; sodium ethanolate; sodium acetate; N-ethyl-N,N-diisopropylamine; HATU; sodium iodide; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 98269-30-8
diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

: 1443300-18-2
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate)

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / ethanol / 1 h / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: water; sodium hydroxide / tetrahydrofuran; ethanol / 16 h / 50 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C

6.1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / 0.33 h / -15 °C

6.2: 18 h / -15 - 20 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; water; hydrogen; sodium ethanolate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;