5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one

Base Information

• Chemical Name: 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one
• CAS No.: 349636-71-1
• Molecular Formula: C₁₈H₂₀N₂O₃S₂
• Molecular Weight: 376.5

Synonyms:5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one

Chemical Property of 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one

Chemical Property:

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Technology Process of 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one

There total 2 articles about 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-thioxothiazolidin-4-one (349636-70-0) + methyl iodide (74-88-4) → 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one (349636-71-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol;

DOI:10.1016/S0960-894X(01)00147-0

Reference yield:

4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzaldehyde (79421-40-2) → 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one (349636-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / β-alanine / acetic acid / 2 h / Heating

2: 99 percent / N,N-diisopropylethylamine / ethanol / 20 °C

With N-ethyl-N,N-diisopropylamine; 3-amino propanoic acid; In ethanol; acetic acid; 1: Knoevenagel condensation;

DOI:10.3987/COM-02-9447

Reference yield: 98.0%

1-methyl-piperazine (109-01-3) + 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-methylsulfanylthiazo-4-one (349636-71-1) → 5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-(4-methylpiperazin-1-yl)thiazol-4-one

Guidance literature:

In tetrahydrofuran; ethanol; Heating;

DOI:10.3987/COM-02-9447

upstream raw materials:

5-[4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)benzylidene]-2-thioxothiazolidin-4-one

methyl iodide

4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzaldehyde

Downstream raw materials:

4-oxo-5-[4-(4-oxopiperidin-1-yl)benzylidene]-4,5-dihydrothiazol-2-yl-cyanamide

N,N-dimethyl-N'-{4-oxo-5-[4-(4-oxopiperidin-1-yl)benzylidene]-4,5-dihydrothiazol-2-yl}guanidine

1-[4-(4-oxo-2-piperidin-1-yl-4H-thiazol-5-ylidenemethyl)phenyl]piperidin-4-one

1-{4-[2-(1-benzylpiperidin-4-ylamino)-4-oxo-4H-thiazol-5-ylidenemethyl]phenyl}piperidin-4-one

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