(R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid

Base Information

Chemical Name:(R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid
CAS No.:153893-81-3
Molecular Formula:C₂₄H₃₁NO₃S₂
Molecular Weight:445.647
Hs Code.:

Synonyms:(R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid

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Chemical Property of (R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid

Chemical Property:

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Technology Process of (R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid

There total 5 articles about (R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

: 3054-01-1,25988-62-9
S-benzyl-L-cysteine

: 153893-79-9
2-Benzylsulfanylmethyl-2-ethyl-butyryl chloride

: 153893-81-3
(R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid

Guidance literature:: With sodium hydroxide; In diethyl ether; for 0.333333h; Ambient temperature;
DOI:10.1248/cpb.41.1066

Reference yield:

: 816-11-5
2-ethyl-butyric acid methyl ester

: 153893-81-3
(R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 79.8 percent / lithium diisopropylamide, hexamethylphosphoramide / tetrahydrofuran; hexane / 1.75 h / -78 - 20 °C

2: 98.2 percent / KOH / ethanol; H₂O / 15.5 h / Heating

3: 100 percent / thionyl chloride / dimethylformamide / 2 h / Ambient temperature

4: 93.8 percent / 2 N aq. NaOH / diethyl ether / 0.33 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.41.1066

Reference yield:

: 3970-13-6
benzyl chloromethyl sulfide

: 153893-81-3
(R)-3-Benzylsulfanyl-2-(2-benzylsulfanylmethyl-2-ethyl-butyrylamino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 79.8 percent / lithium diisopropylamide, hexamethylphosphoramide / tetrahydrofuran; hexane / 1.75 h / -78 - 20 °C

2: 98.2 percent / KOH / ethanol; H₂O / 15.5 h / Heating

3: 100 percent / thionyl chloride / dimethylformamide / 2 h / Ambient temperature

4: 93.8 percent / 2 N aq. NaOH / diethyl ether / 0.33 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.41.1066