(R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate

Base Information

Chemical Name:(R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate
CAS No.:1346517-84-7
Molecular Formula:C₂₀H₂₁NO₅S
Molecular Weight:387.456
Hs Code.:

Synonyms:(R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate

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Chemical Property of (R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate

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Technology Process of (R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate

There total 6 articles about (R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1346517-83-6
ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-oxoacetate

: 1346517-84-7
(R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate

Guidance literature:: ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-oxoacetate; With sodium tetrahydroborate; In methanol; dichloromethane; water; at -40 ℃; for 0.166667h;

With acetic acid; In methanol; dichloromethane; water;

With sodium hydrogencarbonate; In methanol; dichloromethane; water; pH=8;

Reference yield:

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 1346517-84-7
(R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.25 h / 20 °C

2.1: Oxone / dichloromethane / 5 h / 20 °C

3.1: hydrogenchloride / butanone; water / 2 h / 20 °C

3.2: 6 h / 80 °C

4.1: tetrahydrofuran / 20 °C / Inert atmosphere

5.1: sodium tetrahydroborate / dichloromethane; water; methanol / 0.17 h / -40 °C

5.3: pH 8

With hydrogenchloride; Oxone; sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; dichloromethane; water; toluene; butanone;

Reference yield:

: 866392-91-8
2-(benzylsulfonylmethyl)pyridine

: 1346517-84-7
(R,S)-ethyl 2-(1-benzylsulfonyl-2-methylindolizin-3-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / butanone; water / 2 h / 20 °C

1.2: 6 h / 80 °C

2.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / dichloromethane; water; methanol / 0.17 h / -40 °C

3.3: pH 8

With hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane; water; butanone;