1-Benzyl-2,5-dihydro-1H-pyrrole

Base Information

• Chemical Name: 1-Benzyl-2,5-dihydro-1H-pyrrole
• CAS No.: 6913-92-4
• Molecular Formula: C11H13N
• Molecular Weight: 159.231
• Hs Code.: 29339900
• Mol file: 6913-92-4.mol

Synonyms:3-Pyrroline,1-benzyl- (7CI,8CI);1-Benzyl-2,5-dihydro-1H-pyrrole;1-Benzyl-3-pyrroline;N-Benzyl-3-pyrroline;

Chemical Property of 1-Benzyl-2,5-dihydro-1H-pyrrole

Chemical Property:

• Vapor Pressure: 0.083mmHg at 25°C
• Refractive Index: n20/D 1.542(lit.)
• Boiling Point: 226.288 °C at 760 mmHg
• PKA: 8.95±0.50(Predicted)
• Flash Point: 92.222 °C
• PSA: 3.24000
• Density: 1.052 g/cm³
• LogP: 1.99630
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyl-3-pyrroline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45-20

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Benzyl-3-pyrroline was used in synthesis of (S)-1-benzyl-3-hydroxypyrrolidine.

Technology Process of 1-Benzyl-2,5-dihydro-1H-pyrrole

There total 22 articles about 1-Benzyl-2,5-dihydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) → 1-benzyl-2,5-dihydro-1H-pyrrole (6913-92-4)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 5 - 25 ℃; for 12h; Temperature;

Reference yield: 87.0%

N,N-di-2-propenylbenzylamine (4383-26-0) → 1-benzyl-2,5-dihydro-1H-pyrrole (6913-92-4)

Guidance literature:

With titanium(IV) isopropylate; tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; In dichloromethane; at 40 ℃; for 4h;

DOI:10.1021/ol047356q

Reference yield: 82.0%

Z-1,4-dichlorobutene (1476-11-5) + benzylamine (100-46-9) → 1-benzyl-2,5-dihydro-1H-pyrrole (6913-92-4)

Guidance literature:

Z-1,4-dichlorobutene; benzylamine; In dichloromethane; at 5 - 20 ℃; for 24.1667h;

With hydrogenchloride; In dichloromethane; water; at 0 ℃;

upstream raw materials:

3-Pyrroline

pyrrole

benzoyl chloride

N,N-di-2-propenylbenzylamine

Downstream raw materials:

1-benzyl-1H-pyrrole

(S)-N-benzyl-3-hydroxypyrrolidine

(R)-N-benzyl-3-hydroxypyrrolidine

1-benzyl-3-pyrrolidinol