5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile
• CAS No.: 1020058-12-1
• Molecular Formula: C₁₂H₁₂N₄
• Molecular Weight: 212.254
• Mol file: 1020058-12-1.mol

Synonyms:5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile

Chemical Property of 5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile ^*data from reagent suppliers

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Technology Process of 5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile

There total 2 articles about 5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-tolylhydrazine hydrochloride (637-60-5,35467-65-3) + (1-ethoxyethylidene)malononitrile (5417-82-3) → 5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile (1020058-12-1)

Guidance literature:

p-tolylhydrazine hydrochloride; With triethylamine; In ethanol; at 20 ℃; for 0.333333h;

(1-ethoxyethylidene)malononitrile; In ethanol; at 20 ℃; for 1h;

Reference yield:

N-4-methylphenylhydrazine (539-44-6) + (1-ethoxyethylidene)malononitrile (5417-82-3) → 5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile (1020058-12-1)

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2013.06.026

Reference yield:

5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile (1020058-12-1) → 5-bromo-3-methyl-1-(p-tolyl)-1H-pyrazole-4-carbonitrile

Guidance literature:

With copper(I) bromide; isopentyl nitrite; In acetonitrile; at 25 ℃; for 2h; Inert atmosphere;

upstream raw materials:

N-4-methylphenylhydrazine

(1-ethoxyethylidene)malononitrile

p-tolylhydrazine hydrochloride

Downstream raw materials:

N-(3-chloro-5-(((4-cyano-3-methyl-1-(4-methylphenyl)-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

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