4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid

Base Information

Chemical Name:4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid
CAS No.:146939-28-8
Molecular Formula:C₄₀H₄₄N₂O₃
Molecular Weight:600.801
Hs Code.:

Synonyms:4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid

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Chemical Property of 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid

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Technology Process of 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid

There total 8 articles about 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 146923-33-3
ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

: 146939-28-8
4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid

Guidance literature:: With sodium hydroxide; In ethanol; at 40 ℃; for 1h;
DOI:10.1248/cpb.49.799

Reference yield:

: potassium dihydrogen phosphate

: 146923-33-3
ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

: 146939-28-8
4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid

Guidance literature:: With hydrogenchloride; sodium hydroxide; In ethanol; water;

Reference yield:

: 274-40-8
indolizine

: 146939-28-8
4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 37.9 percent / AlCl₃ / CH₂Cl₂ / 1 h / 20 °C

2.1: 56.1 percent / BH₃*THF / tetrahydrofuran / 0.17 h / 20 °C

3.1: AlCl₃ / CH₂Cl₂ / 0.17 h / 20 °C

3.2: 72.6 percent / CH₂Cl₂ / 1 h

4.1: 99.3 percent / H₂ / 10 percent Pd/C / dioxane; ethanol / 4 h / 3040 Torr

5.1: 48.6 percent / iPr₂EtN / CH₂Cl₂ / 20 °C

6.1: 86 percent / 4N aq. NaOH / ethanol / 1 h / 40 °C

With sodium hydroxide; aluminium trichloride; borane-THF; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1.1: Friedel-Crafts acylation / 3.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799