ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

Base Information

Chemical Name:ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate
CAS No.:146923-33-3
Molecular Formula:C₄₂H₄₈N₂O₃
Molecular Weight:628.855
Hs Code.:

Synonyms:ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

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Chemical Property of ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

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Technology Process of ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

There total 7 articles about ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.6%

: bis(4-isobutylphenyl)methyl chloride

: 146922-59-0
ethyl 4-[1-(3-aminobenzoyl)indolizin-3-yl]butyrate

: 146923-33-3
ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1248/cpb.49.799

Reference yield:

: 274-40-8
indolizine

: 146923-33-3
ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 37.9 percent / AlCl₃ / CH₂Cl₂ / 1 h / 20 °C

2.1: 56.1 percent / BH₃*THF / tetrahydrofuran / 0.17 h / 20 °C

3.1: AlCl₃ / CH₂Cl₂ / 0.17 h / 20 °C

3.2: 72.6 percent / CH₂Cl₂ / 1 h

4.1: 99.3 percent / H₂ / 10 percent Pd/C / dioxane; ethanol / 4 h / 3040 Torr

5.1: 48.6 percent / iPr₂EtN / CH₂Cl₂ / 20 °C

With aluminium trichloride; borane-THF; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1.1: Friedel-Crafts acylation / 3.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799

Reference yield:

: 14794-31-1,97900-84-0
ethyl 3-(chloroformyl)propionate

: 146923-33-3
ethyl 4-[1-[3-[[bis(4-isobutylphenyl)methyl]amino]benzoyl]indolizin-3-yl]butyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 37.9 percent / AlCl₃ / CH₂Cl₂ / 1 h / 20 °C

2.1: 56.1 percent / BH₃*THF / tetrahydrofuran / 0.17 h / 20 °C

3.1: AlCl₃ / CH₂Cl₂ / 0.17 h / 20 °C

3.2: 72.6 percent / CH₂Cl₂ / 1 h

4.1: 99.3 percent / H₂ / 10 percent Pd/C / dioxane; ethanol / 4 h / 3040 Torr

5.1: 48.6 percent / iPr₂EtN / CH₂Cl₂ / 20 °C

With aluminium trichloride; borane-THF; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1.1: Friedel-Crafts acylation / 3.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799