2,4-Dichloro-6-fluoroquinoline

Base Information

• Chemical Name: 2,4-Dichloro-6-fluoroquinoline
• CAS No.: 406204-74-8
• Molecular Formula: C9H4Cl2FN
• Molecular Weight: 216.042
• Hs Code.: 2933499090
• Mol file: 406204-74-8.mol

Synonyms:2,4-DICHLORO-6-FLUORO-QUINOLINE

Chemical Property of 2,4-Dichloro-6-fluoroquinoline

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.636
• Boiling Point: 290.139 °C at 760 mmHg
• PKA: -1.80±0.50(Predicted)
• Flash Point: 129.272 °C
• PSA: 12.89000
• Density: 1.491 g/cm³
• LogP: 3.68070

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-6-fluoroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Dichloro-6-fluoroquinoline

There total 4 articles about 2,4-Dichloro-6-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-fluoroaniline (371-40-4) + malonoyl dichloride (1663-67-8) → 2,4-dichloro-6-fluoroquinoline (406204-74-8)

Guidance literature:

at 0 ℃; for 4h; Reflux;

DOI:10.1021/jm5005978

Reference yield: 46.0%

malonic acid (141-82-2) + 4-fluoroaniline (371-40-4) → 2,4-dichloro-6-fluoroquinoline (406204-74-8)

Guidance literature:

With trichlorophosphate; for 5h;

DOI:10.1007/s11164-013-1085-4 DOI:10.2174/1573406411666150430132055

Reference yield:

6-fluoro-4-hydroxy-1H-quinolin-2-one (1677-37-8) → 2,4-dichloro-6-fluoroquinoline (406204-74-8)

Guidance literature:

With trichlorophosphate; for 2h; Reflux;

DOI:10.1016/j.bioorg.2022.105631

upstream raw materials:

malonic acid

4-fluoroaniline

malonoyl dichloride

6-fluoro-4-hydroxy-1H-quinolin-2-one

Downstream raw materials:

2-chloro-6-fluoro-4-methoxy-quinoline

dimethyl 4-(4-(2-chloro-6-fluoroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate

C₂₈H₂₆ClFN₂O₅

4-((1-((4,5-dimethylisoxazol-3-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one

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