3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Base Information

Chemical Name:3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CAS No.:1268476-75-0
Molecular Formula:C₂₆H₂₆N₄O₃
Molecular Weight:442.517
Hs Code.:

Synonyms:3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Chemical Property of 3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Technology Process of 3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

There total 11 articles about 3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 504-24-5
4-aminopyridine

: 1268476-87-4
3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]-pyridine-2-carboxylic acid

: 1268476-75-0
3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 1186188-51-1
ethyl 4-chloro-6-ethyl-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1268476-75-0
3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C

2: triethylamine / ethanol / 25 h / 80 - 100 °C

3: pyridine / 3 h / 60 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 3 h / 100 °C / Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 10 - 35 °C

6: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 10 - 35 °C

7: sodium hydroxide; water / ethanol / 3 h / 70 °C

8: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 70 °C

With pyridine; tetrapropylammonium perruthennate; water; hydrogen; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1186188-52-2
ethyl 4-chloro-6-ethyl-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydropyridine-3-carboxylate

: 1268476-75-0
3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(pyridin-4-yl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / ethanol / 25 h / 80 - 100 °C

2: pyridine / 3 h / 60 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 3 h / 100 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 10 - 35 °C

5: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 10 - 35 °C

6: sodium hydroxide; water / ethanol / 3 h / 70 °C

7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 70 °C

With pyridine; tetrapropylammonium perruthennate; water; hydrogen; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;