4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate

Base Information

Chemical Name:4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate
CAS No.:676347-10-7
Molecular Formula:C₃₁H₄₄N₂O₁₀SSi
Molecular Weight:664.849
Hs Code.:

4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate

Synonyms:4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate

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Chemical Property of 4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate

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Technology Process of 4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate

There total 3 articles about 4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 676346-96-6
methyl (R)-2-((S)-3-hydroxybutyrylamino)-3-mercaptopropionate

: 147215-02-9
4-nitrobenzyl-3-[(tert-butyl)dimethylsilyloxy]-5-methoxy-2,6-dimethylbenzoate

: 676347-10-7
4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate

Guidance literature:: 4-nitrobenzyl-3-[(tert-butyl)dimethylsilyloxy]-5-methoxy-2,6-dimethylbenzoate; With N-Bromosuccinimide; In tetrachloromethane; Heating; irradiation;

methyl (R)-2-((S)-3-hydroxybutyrylamino)-3-mercaptopropionate; With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0310232

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 676347-10-7
4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / Et₃N / dimethylformamide / 0 °C

2.1: NBS / CCl₄ / Heating; irradiation

2.2: 24 percent / Et₃N / CH₂Cl₂ / 20 °C

With N-Bromosuccinimide; triethylamine; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0310232

Reference yield:

: 676346-99-9
4-nitrobenzyl 3-hydroxy-5-methoxy-2,6-dimethylbenzoate

: 676347-10-7
4-nitrobenzyl 3-[(tert-butyl)dimethylsilyloxy]-2-[(R)-2[((S)-3-hydroxybutyrylamino)-2-methoxycarbonylethyl]sulfanylmethyl]-5-methoxy-6-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / Et₃N / dimethylformamide / 0 °C

2.1: NBS / CCl₄ / Heating; irradiation

2.2: 24 percent / Et₃N / CH₂Cl₂ / 20 °C

With N-Bromosuccinimide; triethylamine; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0310232