6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid

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Chemical Name:6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid
CAS No.:1266105-08-1
Molecular Formula:C₂₈H₂₇N₃O₇
Molecular Weight:517.538
Hs Code.:

Synonyms:6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid

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Chemical Property of 6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid

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Technology Process of 6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid

There total 3 articles about 6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1266105-20-7
tert-butyl 6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy) pyrimidin-2-yl)hexanoate

: 1266105-08-1
6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.333333h; chemoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.11.054

Reference yield:

: 1266105-19-4
tert-butyl 6-(4-chloro-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoate

: 1266105-08-1
6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 85 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere

With caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2010.11.054

Reference yield:

: 163041-47-2
(Z)-3-methoxy-2-iodo-acrylic acid methyl ester

: 1266105-08-1
6-(4-(2-cyanophenoxy)-6-(2-((E)-1-(methoxycarbonyl)-2-methoxyvinyl)phenoxy)pyrimidin-2-yl)hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 10 h / 90 °C / Inert atmosphere

2: 10% palladium on activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C / 3040.2 Torr

3: caesium carbonate / N,N-dimethyl-formamide / 3.5 h / 0 - 20 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 4 h / 85 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10% palladium on activated carbon; hydrogen; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2010.11.054