2-Acetyl-3-fluoropyridine

Base Information

Chemical Name:2-Acetyl-3-fluoropyridine
CAS No.:87674-20-2
Molecular Formula:C7H6FNO
Molecular Weight:139.129
Hs Code.:2933399090
DSSTox Substance ID:DTXSID00520591
Wikidata:Q72435209
Mol file:87674-20-2.mol

Synonyms:2-ACETYL-3-FLUOROPYRIDINE;87674-20-2;1-(3-fluoropyridin-2-yl)ethanone;1-(3-Fluoro-2-pyridinyl)ethanone;1-(3-FLUOROPYRIDIN-2-YL)ETHAN-1-ONE;MFCD06659495;ETHANONE, 1-(3-FLUORO-2-PYRIDINYL)-;1-(3-fluoro-2-pyridyl)ethanone;SCHEMBL1812108;DTXSID00520591;CCZMVVFNNQQTFC-UHFFFAOYSA-N;AKOS006295108;AM85388;CS-W021536;PB26212;AC-33325;DS-12734;SY022346;EN300-177396;P10386;J-503140

Suppliers and Price of 2-Acetyl-3-fluoropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Acetyl-3-fluoropyridine
500mg
$ 75.00

Matrix Scientific
2-Acetyl-3-fluoropyridine 95+%
1g
$ 325.00

Matrix Scientific
2-Acetyl-3-fluoropyridine 95+%
5g
$ 655.00

J&W Pharmlab
2-ACETYL-3-FLUOROPYRIDINE 97%
25g
$ 340.00

J&W Pharmlab
2-ACETYL-3-FLUOROPYRIDINE 97%
5g
$ 90.00

Frontier Specialty Chemicals
2-Acetyl-3-fluoropyridine 97%
5g
$ 75.00

Frontier Specialty Chemicals
2-Acetyl-3-fluoropyridine 97%
1g
$ 25.00

Frontier Specialty Chemicals
2-Acetyl-3-fluoropyridine 97%
25g
$ 300.00

Crysdot
2-Acetyl-3-fluoropyridine 98%
10g
$ 174.00

Chemenu
2-Acetyl-3-fluoropyridine 98%
10g
$ 163.00

Total 58 raw suppliers

Chemical Property of 2-Acetyl-3-fluoropyridine

Chemical Property:

Refractive Index:1.492
Boiling Point:179.7 °C at 760 mmHg
PKA:0.53±0.10(Predicted)
Flash Point:62.5 °C
PSA：29.96000
Density:1.175 g/cm³
LogP:1.42330
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:139.043341977
Heavy Atom Count:10
Complexity:138

Purity/Quality:

99%, ^*data from raw suppliers

2-Acetyl-3-fluoropyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=C(C=CC=N1)F

Technology Process of 2-Acetyl-3-fluoropyridine

There total 3 articles about 2-Acetyl-3-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 87674-14-4
2-(1-hydroxyethyl)-3-fluoropyridine

: 87674-20-2
1-(3-fluoropyridin-2-yl)ethanone

Guidance literature:: With manganese(IV) oxide; In toluene; Heating;
DOI:10.1016/S0040-4020(01)91919-2

Reference yield:

: 372-47-4
3-Fluoropyridine

: 78191-00-1
N-Methoxy-N-methylacetamide

: 87674-20-2
1-(3-fluoropyridin-2-yl)ethanone

: 87674-21-3
4-acetyl-3-fluoropyridine

Guidance literature:: 3-Fluoropyridine; With n-butyllithium;

N-Methoxy-N-methylacetamide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.bmcl.2009.11.060

Reference yield:

: 372-47-4
3-Fluoropyridine

: 87674-20-2
1-(3-fluoropyridin-2-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi, TMEDA / 1) diethyl ether, -75 deg C, 4 hr

2: 85 percent / MnO₂ / toluene / Heating

With manganese(IV) oxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In toluene;
DOI:10.1016/S0040-4020(01)91919-2