(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

Base Information

Chemical Name:(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid
CAS No.:168553-64-8
Molecular Formula:C₁₆H₂₇NO₅SSi
Molecular Weight:373.546
Hs Code.:

Synonyms:(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

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Chemical Property of (S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

Chemical Property:

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Technology Process of (S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

There total 5 articles about (S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2-Trimethylsilanyl-ethanesulfonic acid ((S)-2-benzyloxy-1-formyl-1-methyl-ethyl)-amide

: 168553-64-8
(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; isobutene; In tetrahydrofuran; water; for 2h;
DOI:10.1016/0040-4039(95)00621-I

Reference yield:

: 106018-85-3
2-trimethylsilanyl-ethanesulfonyl chloride

: 168553-64-8
(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NEt₃

2: NaH / dioxane

3: TsOH / methanol

4: 1) Py-SO₃, Et₃N, 2) NaClO₂, NaH₂PO₄ / 1) DMSO, CH₂Cl₂, 2) THF, H₂O

With sodium chlorite; sodium dihydrogenphosphate; sulfur trioxide pyridine complex; sodium hydride; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1055/s-1997-681

Reference yield:

: 168553-71-7
(S)-2-methyl-1-(2-trimethylsilanyl-ethanesulfonyl)-2trityloxymethyl-aziridine

: 168553-64-8
(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dioxane

2: TsOH / methanol

3: 1) Py-SO₃, Et₃N, 2) NaClO₂, NaH₂PO₄ / 1) DMSO, CH₂Cl₂, 2) THF, H₂O

With sodium chlorite; sodium dihydrogenphosphate; sulfur trioxide pyridine complex; sodium hydride; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1055/s-1997-681