3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid

Base Information

Chemical Name:3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid
CAS No.:528885-34-9
Molecular Formula:C₃₅H₃₈N₄O₅
Molecular Weight:594.711
Hs Code.:

Synonyms:3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid

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Chemical Property of 3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid

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Technology Process of 3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid

There total 11 articles about 3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 942232-13-5
C₃₇H₄₂N₄O₅

: 528885-34-9
3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 21h;
DOI:10.1021/jm070139l

Reference yield:

: 13331-27-6
m-nitrobenzene boronic acid

: 528885-34-9
3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 15 percent / NEt₃; PPh₃ / Pd(OAc)2 / dimethylformamide / 3.5 h / 100 °C

2: 94 percent / SnCl₂*H₂O / ethyl acetate / 3 h / Heating

3: 83 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

4: 100 percent / aq. NaOH / ethanol / 21 h / 20 °C

With dmap; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; tin(ll) chloride; palladium diacetate; In ethanol; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm070139l

Reference yield:

: 528882-09-9
(5-cyclohexyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester

: 528885-34-9
3'-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-biphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 84 percent / dimethylformamide / 2 h / 20 °C

2.1: 95 percent / aq. NaOH / ethanol / 16 h / 20 °C

3.1: 83 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

4.1: 100 percent / aq. NaOH / ethanol / 21 h / 20 °C

With dmap; sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l