[(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane

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Chemical Name:[(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane
CAS No.:213917-69-2
Molecular Formula:C₂₄H₄₂O₄Si
Molecular Weight:422.681
Hs Code.:

Synonyms:[(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane

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Chemical Property of [(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane

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Technology Process of [(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane

There total 2 articles about [(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 111828-39-8
(2S,3S)-1-benzyloxy-2,3-isopropylidenedioxy-4-(S)-octanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 213917-69-2
[(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 40 ℃; for 38h;
DOI:10.1016/S0957-4166(98)00221-3

Reference yield:

: 81028-12-8
(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde

: 213917-69-2
[(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 544 mg / diethyl ether / 15 h / 0 - 20 °C

2: 90 percent / imidazole / dimethylformamide / 38 h / 40 °C

With 1H-imidazole; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(98)00221-3

Reference yield:

: 213917-69-2
[(S)-1-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentyloxy]-tert-butyl-dimethyl-silane

: 213917-82-9
Toluene-4-sulfonic acid (1R,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-ethynyl-hexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Na, NH₃(liq.) / 4 h / -33 °C

2: 78 percent / CCl₄, Ph₃P / 3 h / 80 °C

3: 72 percent / LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C

4: 84 percent / pyridine / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; tetrachloromethane; ammonia; sodium; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0957-4166(98)00221-3