6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole

Base Information

Chemical Name:6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole
CAS No.:1421503-50-5
Molecular Formula:C₂₁H₂₂FIN₂O₂
Molecular Weight:480.321
Hs Code.:

Synonyms:6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole

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Chemical Property of 6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole

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Technology Process of 6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole

There total 10 articles about 6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 1421503-49-2
6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1H-indazole

: 1421503-50-5
6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole

Guidance literature:: 3,4-dihydro-2H-pyran; 6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1H-indazole; With toluene-4-sulfonic acid; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 79762-54-2
6-bromo-1H-indazole

: 1421503-50-5
6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / tetrahydrofuran / 60 °C

2.1: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

3.1: hydrogenchloride / water; methanol / 60 °C

4.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h

4.2: 0 - 20 °C

5.1: toluene-4-sulfonic acid / dichloromethane / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; toluene-4-sulfonic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1234845-77-2
4-ethyl-1-fluoro-2-methoxy-benzene

: 1421503-50-5
6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-3-iodo-1-(tetrahydro-pyran-2-yl)-1H-indazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / acetonitrile / 18 h / 20 °C

2.1: triethylamine; dichloro bis(acetonitrile) palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

4.1: hydrogenchloride; water / methanol / 60 °C

5.1: potassium hydroxide / N,N-dimethyl-formamide / 0.08 h

5.2: 0.5 h / 20 °C

6.1: toluene-4-sulfonic acid / dichloromethane / 0 - 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; dichloro bis(acetonitrile) palladium(II); potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;