(3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile

Base Information

Chemical Name:(3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile
CAS No.:899798-71-1
Molecular Formula:C₂₅H₃₅NO₃Si
Molecular Weight:425.643
Hs Code.:

Synonyms:(3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile

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Chemical Property of (3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile

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Technology Process of (3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile

There total 3 articles about (3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 899798-69-7
(2S,3S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-methoxymethoxy-2-methyl-pentan-1-ol

: 899798-71-1
(3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2: 97 percent / dimethylsulfoxide / 2 h / 80 °C

With triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/chem.200700342

Reference yield:

: 899798-67-5
(2R,3S)-5-(tert-Butyl-diphenyl-silanyloxy)-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-hydroxy-2-methyl-pentan-1-one

: 899798-71-1
(3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / iPr₂NEt / CH₂Cl₂ / 4 h / Heating

2: 94 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

3: 87 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

4: 97 percent / dimethylsulfoxide / 2 h / 80 °C

With lithium aluminium tetrahydride; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/chem.200700342

Reference yield:

: 112897-03-7
3-(tert-butyldiphenylsilyloxy)-1-propanal

: 899798-71-1
(3S,4S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-3-methyl-hexanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: nBu₂BOTf; N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / -5 °C

1.2: 94 percent / CH₂Cl₂ / 16 h / -78 °C

2.1: 91 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 4 h / Heating

3.1: 94 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C

4.1: 87 percent / triethylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 16 h / 20 °C

5.1: 97 percent / dimethylsulfoxide / 2 h / 80 °C

With dmap; lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol060669w