2-Bromo-4-hydroxypyridine

Base Information

• Chemical Name: 2-Bromo-4-hydroxypyridine
• CAS No.: 36953-40-9
• Molecular Formula: C5H4BrNO
• Molecular Weight: 173.997
• Hs Code.: 2933399090
• European Community (EC) Number: 818-609-2
• DSSTox Substance ID: DTXSID10376501
• Wikidata: Q72457013
• Mol file: 36953-40-9.mol

Synonyms:2-BROMO-4-HYDROXYPYRIDINE;36953-40-9;2-Bromopyridin-4-ol;2-bromo-1H-pyridin-4-one;4-PYRIDINOL, 2-BROMO-;2-Bromo-pyridin-4-ol;MFCD00234040;2-Bromo-4-hydroxy pyridine;2-bromo-1,4-dihydropyridin-4-one;4-hydroxy-2-bromo-pyridine;SCHEMBL179116;SCHEMBL10855044;DTXSID10376501;GGXSDQDNOMWAFV-UHFFFAOYSA-N;AMY19933;AKOS005198976;AB05095;CS-W004923;AC-26853;TS-02398;A6358;B5431;FT-0650326;FT-0659882;EN300-141548;F89019;J-508302

Chemical Property of 2-Bromo-4-hydroxypyridine

Chemical Property:

• Appearance/Colour: Light yellow cryst
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 173 °C(Solv: water (7732-18-5))
• Refractive Index: 1.614
• Boiling Point: 425.038 °C at 760 mmHg
• PKA: 7.94±0.10(Predicted)
• Flash Point: 210.856 °C
• PSA: 33.12000
• Density: 1.789 g/cm³
• LogP: 1.54970
• Solubility.: soluble in Methanol
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.94763
• Heavy Atom Count: 8
• Complexity: 171

Purity/Quality:

99% ^*data from raw suppliers

2-Bromopyridin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC(=CC1=O)Br

Technology Process of 2-Bromo-4-hydroxypyridine

There total 3 articles about 2-Bromo-4-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-bromo-4-fluoro-pyridine (357927-50-5) → 2-bromo-4-hydroxylpyridine (36953-40-9)

Guidance literature:

With 18-crown-6 ether; potassium hydroxide; In neat (no solvent); for 1h; Milling; Sealed tube; Green chemistry;

DOI:10.1039/d1gc04361g

Reference yield:

→ 2-bromo-4-hydroxylpyridine (36953-40-9)

Guidance literature:

Reference yield:

→ 2-bromo-4-hydroxylpyridine (36953-40-9)

Guidance literature:

2-Brom-4-nitro-pyridin, 1)Erhitzen mit wss. KOH,2) HCl;

upstream raw materials:

2-bromo-4-fluoro-pyridine

Downstream raw materials:

4-benzyloxy-2-bromo-pyridine

2-bromo-4-cyclopentyloxy-pyridine

2-bromo-4-methoxypyridine

C₁₅H₁₅F₂NO