6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide

Base Information

Chemical Name:6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide
CAS No.:1387641-57-7
Molecular Formula:C₂₆H₂₄ClN₃O₅
Molecular Weight:493.947
Hs Code.:

Synonyms:6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide

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Chemical Property of 6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide

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Technology Process of 6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide

There total 7 articles about 6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.8%

: 1387641-91-9
4-chloro-3-(6,7-dimethoxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxamido)benzoic acid

: 100-46-9
benzylamine

: 1387641-57-7
6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 24844-72-2
(4,5-dimethoxy-2-nitro-benzylidene)-malonic acid diethyl ester

: 1387641-57-7
6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; water; sodium cyanoborohydride / ethanol

2.1: acetic acid; iron / methanol / 1.5 h / 90 - 100 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1.5 h / 20 °C

3.2: Acidic conditions

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 20 °C

5.1: water; lithium hydroxide / dimethyl sulfoxide; tetrahydrofuran; methanol / 72 h

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogenchloride; water; iron; sodium cyanoborohydride; acetic acid; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1387641-90-8
6,7-dimethoxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid

: 1387641-57-7
6,7-Dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: water; lithium hydroxide / dimethyl sulfoxide; tetrahydrofuran; methanol / 72 h

3: triethylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With water; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;