Technology Process of 4-chloro-3-(6,7-dimethoxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxamido)benzoic acid
There total 6 articles about 4-chloro-3-(6,7-dimethoxy-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxamido)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-chloro-3-[(6,7-dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carbonyl)-amino]-benzoic acid methyl ester;
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol; dimethyl sulfoxide;
for 72h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; iron / methanol / 1.5 h / 90 - 100 °C
2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1.5 h / 20 °C
2.2: Acidic conditions
3.1: triethylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 20 °C
4.1: water; lithium hydroxide / dimethyl sulfoxide; tetrahydrofuran; methanol / 72 h
With
water; iron; acetic acid; triethylamine; HATU; lithium hydroxide;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; water; sodium cyanoborohydride / ethanol
2.1: acetic acid; iron / methanol / 1.5 h / 90 - 100 °C
3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1.5 h / 20 °C
3.2: Acidic conditions
4.1: triethylamine; HATU / N,N-dimethyl-formamide / 1.5 h / 20 °C
5.1: water; lithium hydroxide / dimethyl sulfoxide; tetrahydrofuran; methanol / 72 h
With
hydrogenchloride; water; iron; sodium cyanoborohydride; acetic acid; triethylamine; HATU; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
![4-chloro-3-[(6,7-dimethoxy-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carbonyl)-amino]-benzoic acid methyl ester](/Databaselist/images/loading.webp)
