(R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid

Base Information

Chemical Name:(R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid
CAS No.:301209-16-5
Molecular Formula:C₃₃H₄₃FN₄O₂
Molecular Weight:546.728
Hs Code.:

Synonyms:(R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid

Suppliers and Price of (R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid

There total 5 articles about (R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 679400-60-3
(R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid benzyl ester

: 301209-16-5
(R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2003.12.006

Reference yield:

: 103-80-0
phenylacetyl chloride

: 301209-16-5
(R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Pd(PPh₃)4 / 1,2-dichloro-ethane / Heating

2.1: ethanol / 60 - 80 °C

2.2: HCl / methanol

3.1: NaBH(OAc)3; DIEA / 1,2-dichloro-ethane

4.1: H₂ / Pd/C / methanol

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2003.12.006

Reference yield:

: 301219-18-1
4-(3-benzyl-1-ethyl-pyrazol-5-yl)piperidine

: 301209-16-5
(R)-2-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-yl]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH(OAc)3; DIEA / 1,2-dichloro-ethane

2: H₂ / Pd/C / methanol

With hydrogen; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2003.12.006