N₄-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine

Base Information

• Chemical Name: N₄-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine
• CAS No.: 1315494-62-2
• Molecular Formula: C₂₅H₂₇N₅O₂S
• Molecular Weight: 461.588

Synonyms:N₄-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine

Chemical Property of N₄-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₄-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine

There total 5 articles about N₄-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-amine (1315494-61-1) → N4-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine (1315494-62-2)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 4h; Reflux;

DOI:10.1021/jm300438j

Reference yield:

4-chloro-7-azaindole (55052-28-3) → N4-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine (1315494-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 23.5 h / -5 - 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.17 h / 120 °C / Microwave irradiation

4: iron; ammonium chloride / ethanol; water / 4 h / Reflux

With dmap; tetrabutylammonium nitrate; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In ethanol; dichloromethane; water; isopropyl alcohol;

DOI:10.1021/jm300438j

Reference yield:

benzenesulfonyl chloride (98-09-9) → N4-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine (1315494-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 23.5 h / -5 - 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.17 h / 120 °C / Microwave irradiation

4: iron; ammonium chloride / ethanol; water / 4 h / Reflux

With dmap; tetrabutylammonium nitrate; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In ethanol; dichloromethane; water; isopropyl alcohol;

DOI:10.1021/jm300438j

upstream raw materials:

1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

N-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-amine

benzenesulfonyl chloride

4-chloro-7-azaindole

Downstream raw materials:

1-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

1-[(3R)-1-benzylpiperidin-3-yl]-6-(phenylsulfonyl)-1,6-dihydropyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridine

1-((R)-1-benzyl-piperidin-3-yl)-1,6-dihydro-1,2,3,5,6-pentaaza-as-indacene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1315494-62-2 N₄-[(3R)-1-(phenylmethyl)-piperidin-3-yl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send