3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid

Base Information

Chemical Name:3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid
CAS No.:908607-39-6
Molecular Formula:C₂₉H₂₉N₂O₇P
Molecular Weight:548.532
Hs Code.:

Synonyms:3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid

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Chemical Property of 3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid

Chemical Property:

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Technology Process of 3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid

There total 1 articles about 3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 932-90-1
Benzaldoxime

: 2-{[((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)(hydroxy)phosphoryl]methyl}pent-4-ynoic acid

: 908607-39-6
3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid

Guidance literature:: Benzaldoxime; With pyridine; N-chloro-succinimide; In chloroform; at 20 - 45 ℃;

2-{[((1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)(hydroxy)phosphoryl]methyl}pent-4-ynoic acid; With triethylamine; at 45 ℃;
DOI:10.1021/jm9010803

Reference yield:

: 908607-39-6
3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid

: 17083-23-7
2-amino-3-(4-tert-butoxy-phenyl)-propionic acid tert-butyl ester

: 908607-48-7
C₄₆H₅₄N₃O₉P

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm9010803

Reference yield:

: 908607-39-6
3-[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)phosphinyl]-2-[(3-phenylisoxazol-5-yl)methyl]propanoic acid

: 15100-75-1,75898-47-4
L-phenylalanine tert-butyl ester hydrochloride

: 908607-45-4
C₄₂H₄₆N₃O₈P

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm9010803