N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester

Base Information

Chemical Name:N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester
CAS No.:103300-55-6
Molecular Formula:C₃₇H₄₂N₂O₇
Molecular Weight:626.75
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester

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Chemical Property of N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester

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Technology Process of N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester

There total 15 articles about N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2419-54-7
N-(benzyloxycarbonyl)-β-benzyl-L-aspartic acid p-nitrophenyl ester

: 103300-54-5
D-phenylglycine (-)-α-fenchyl ester

: 103300-55-6
N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester

Guidance literature:: In tetrahydrofuran; for 24h;
DOI:10.1021/jm00165a027

Reference yield:

: 875-74-1
(R)-phenylglycine

: 103300-55-6,124510-62-9,124510-63-0,124510-64-1,124510-65-2
(S)-3-Benzyloxycarbonylamino-N-[phenyl-((1S,2R,4R)-1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yloxycarbonyl)-methyl]-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / 2N NaOH / dioxane / 2 h

2: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) -78 deg C, 0.5 h, 2.) -23 deg C

3: 5N HCl / acetone

4: tetrahydrofuran / 24 h

With hydrogenchloride; dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone;
DOI:10.1021/jm00165a027

Reference yield:

: 875-74-1
(R)-phenylglycine

: 103300-55-6
N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / 2N NaOH / dioxane / 2 h

2: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) -78 deg C, 0.5 h, 2.) -23 deg C

3: 44 percent / 5N HCl / acetone

4: 100 percent / tetrahydrofuran / 24 h

With hydrogenchloride; dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone;
DOI:10.1021/jm00165a027