(S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Base Information

Chemical Name:(S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
CAS No.:1269440-99-4
Molecular Formula:C₂₃H₂₉ClFN₇O₆S₂
Molecular Weight:618.11
Hs Code.:

(S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Synonyms:(S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

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Chemical Property of (S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

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Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of (S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

There total 19 articles about (S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269440-78-9
(S)-methyl 1-(4-(3-(3-amino-5-chloro-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

: 124-63-0
methanesulfonyl chloride

: 1269440-99-4
(S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Guidance literature:: (S)-methyl 1-(4-(3-(3-amino-5-chloro-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate; methanesulfonyl chloride; With triethylamine; In 2-methyltetrahydrofuran; at -5 - 20 ℃;

With hydrogenchloride; In 2-methyltetrahydrofuran; water; pH=6 - 6.5;

In 2-methyltetrahydrofuran; water; at 20 ℃; for 0.166667h; pH=7 - 7.5;

Reference yield:

: 89897-29-0
3-amino-1-isopropyl-1H-pyrazole-4-carbonitrile

: 1269440-99-4
(S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrahydrofuran; diethyl ether / 0 °C / Reflux

1.2: pH 7

2.1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0 - 20 °C

2.2: pH 9 - 10

3.1: 12 h / 155 °C

4.1: lithium hydroxide / iso-butanol / 20 h / 110 °C

5.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C

6.1: trichlorophosphate / 16 h / 110 °C

7.1: triethylamine / 1,4-dioxane; isopropyl alcohol / 48 h / 125 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 80 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

10.1: triethylamine / 2-methyltetrahydrofuran / -5 - 20 °C

10.2: pH 6 - 6.5

10.3: 0.17 h / 20 °C / pH 7 - 7.5

With sodium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; potassium iodide; lithium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile; iso-butanol;

Reference yield:

: 97619-92-6
2-((2-benzylidene-1-isopropylhydrazinyl)methylene)malononitrile

: 1269440-99-4
(S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: hydrogenchloride / ethanol; water / 0.33 h / Reflux

2.1: tetrahydrofuran; diethyl ether / 0 °C / Reflux

2.2: pH 7

3.1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 0 - 20 °C

3.2: pH 9 - 10

4.1: tert-Butoxybis(dimethylamino)methane / 114 - 120 °C / Inert atmosphere

5.1: lithium hydroxide / iso-butanol / 20 h / 110 °C

6.1: trifluoroacetic acid; sodium nitrite / 0 - 20 °C

7.1: trichlorophosphate / 16 h / 110 °C

8.1: triethylamine / 1,4-dioxane; isopropyl alcohol / 48 h / 125 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 16 h / 80 °C

10.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

11.1: triethylamine / 2-methyltetrahydrofuran / -5 - 20 °C

11.2: pH 6 - 6.5

11.3: 0.17 h / 20 °C / pH 7 - 7.5

With hydrogenchloride; tert-Butoxybis(dimethylamino)methane; sodium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; potassium iodide; lithium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile; iso-butanol;